MMG-11, CAS 313254-94-3

Formulation: A solid

Formal Name: 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]-2-furancarboxylic acid

Purity: ≥95%

Formula Markup: C15H14O7

Formula Weight: 306,3

Shelf life (days): 1460

CAS Number: 313254-94-3

Notes: MMG-11 is an antagonist of the toll-like receptor 1/2 (TLR1/2) heterodimer (IC50 = 0.9 µM in HEK-Blue cells expressing the human receptors).{66437} It is selective for TLR1/2 over the TLR2/6 heterodimer (IC50 = 7.4 µM in HEK-Blue cells expressing the human receptors). MMG-11 inhibits TNF-α and IL-6 cytokine secretion induced by the bacterial lipopeptide agonist of TLR2, Pam3CKS4 (Item No. 24126), in RAW 264.7 macrophages (IC50s = 3.3 and 0.2 µM, respectively). It increases serotonin transporter (SERT) and glutathione (GSH) activity, as well as decreases lactate dehydrogenase (LDH) activity and malondialdehyde (MDA) levels, in M. avium-infected Caco-2 cells when used at a concentration of 5 ng/ml.{66438}

• Artikelnummer: CAY38787-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38787-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK