Molindone (hydrochloride), CAS 15622-65-8

Formulation: A crystalline solid

Formal Name: 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one, monohydrochloride

Purity: ≥98%

Formula Markup: C16H24N2O2 • HCl

Formula Weight: 312,8

Shelf life (days): 1460

CAS Number: 15622-65-8

Notes: Molindone is a dopamine receptor antagonist.{39737} It selectively inhibits radioligand binding to dopamine D2 receptors in rat brain homogenates (IC50s = 56 and >10,000 nM for D2 and D1 receptors, respectively), however, it inhibits radioligand binding to both D2 and D1 receptors in vivo (ED50s = 4.9 and 51 mg/kg, respectively). Molindone (0.4-0.8 mg/kg) reverses depression of dopamine neurons induced by D-amphetamine and apomorphine (Item No. 16094) and increases dopamine synthesis and dihydroxyphenylacetic acid levels in the striatum and olfactory tubercles in rats.{39738} It suppresses spontaneous locomotion and blocks conditioned avoidance responses in male mice and female rats.{39741} It inhibits climbing behavior in mice induced by the D2 receptor agonist bromocriptine (Item No. 14598).{39739} Molindone (0.3-5.6 mg/kg) increases error rates and reduces response rate in pigeons following learned acquisition.{39740} Formulations containing molindone have been used in the treatment of schizophrenia.

• Artikelnummer: CAY23841-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23841-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK