Mosapride (citrate), CAS 112885-42-4

Formulation: A solid

Formal Name: 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide, 2-hydroxy-1,2,3-monopropanetricarboxylate

Purity: ≥98%

Formula Markup: C21H25ClFN3O3 • C6H8O7

Formula Weight: 614

Shelf life (days): 1460

CAS Number: 112885-42-4

Notes: Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM).{52440,30682} It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM).{52440,30682} It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively).{39019} Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs.{52440} It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.

• Artikelnummer: CAY30048-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30048-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK