Motolimod, CAS 926927-61-9

Formulation: A crystalline solid

Formal Name: 2-amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide

Purity: ≥98%

Formula Markup: C28H34N4O2

Formula Weight: 458,6

Shelf life (days): 1460

CAS Number: 926927-61-9

Notes: Motolimod is an agonist of toll-like receptor 8 (TLR8).{36954} It increases the production of TNF-α and IL-12 in human peripheral blood mononuclear cells (PBMCs; EC50s = 140 and 120 nM, respectively), monocytes, and myeloid dendritic cells. Motolimod also increases IFN-γ production in natural killer (NK) cells and increases cytolysis in K562 NK cell-sensitive leukemia cells when used at concentrations of 167 and 500 nM for 48 hours. It increases plasma levels of a group of human cytokines, including IL-6, IL-12p70, TNF-α, MCP-1, and MIP-1β, in NOD-scid IL2rynull (NSG) mice reconstituted with human immune system (NSG-HIS) when administered at doses of 1.5 and 15 mg/m2.{36953} Motolimod, when used in combination with pegylated liposomal doxorubicin (PLD), reduces tumor growth and increases tumor infiltration of monocytes and T cells in an ovarian cancer NSG-HIS mouse model.

• Artikelnummer: CAY22952-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22952-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK