Mozavaptan-d6, CAS 2750534-83-7

Formulation: A solid

Formal Name: N-[4-[[5-(dimethyl-d6-amino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-benzamide

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C27H23D6N3O2

Formula Weight: 433,6

Shelf life (days): 1460

CAS Number: 2750534-83-7

Notes: Mozavaptan-d6 is intended for use as an internal standard for the quantification of mozavaptan (Item No. 16664) by GC- or LC-MS. Mozavaptan is an orally bioavailable antagonist of vasopressin V2 receptors (Ki = 9.42 nM in HeLa cells expressing the human receptor).{27292,59329} It is selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes that endogenously express high levels of vasopressin V2 and V1 receptors, respectively.{27292} Mozavaptan (10-30 mg/kg, p.o.) increases urine volume and decreases urine osmolality, indicating aquaresis, in conscious rats. It reduces decreases in urine flow and increases in urine osmolality induced by arginine vasopressin (AVP; Item No. 24154) in anesthetized rats when administered intravenously at doses ranging from 10 to 100 µg/kg.

• Artikelnummer: CAY31321-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31321-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung