Mycophenolic Acid methyl ester, CAS 31858-66-9

Formulation: A crystalline solid

Formal Name: (4E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid, methyl ester

Purity: ≥98%

Formula Markup: C18H22O6

Formula Weight: 334,4

Shelf life (days): 730

CAS Number: 31858-66-9

Notes: Mycophenolic acid methyl ester is an esterified form of the immunosuppressive microbial metabolite mycophenolic acid (Item No. 21716) that has been found in P. spartinae.{69314} It inhibits transactivation of peroxisome proliferator-activated receptor γ (PPARγ) induced by the PPARγ agonist pioglitazone (Item Nos. 71745 / 22263 / 10028) in U2OS cells in a reporter assay when used at concentrations of 1 and 10 µM.{69315} Mycophenolic acid methyl ester is cytotoxic against a panel of seven cancer cell lines (IC50s = 0.26-23.73 µM).{69316} It inhibits tumor growth in an Ehrlich murine spontaneous adenocarcinoma model and decreases the production of antibodies against sheep red blood cells in mice when administered at a dose of 120 mg/kg.{69317} Mycophenolic acid methyl ester has been used as a precursor in the synthesis of mycophenolic acid β-D-glucuronide (Item No. 19078).{69318} It is also a potential impurity in commercial preparations of the mycophenolic acid prodrug mycophenolate mofetil.{62891}

• Artikelnummer: CAY38397-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38397-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe