N-Desbutyl Dronedarone (hydrochloride), CAS 197431-02-0

Formulation: A solid

Formal Name: N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride

Purity: ≥95%

Formula Markup: C27H36N2O5S • HCl

Formula Weight: 537,1

Shelf life (days): 1460

CAS Number: 197431-02-0

Notes: N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone (Item No. 9000543).{58755,58756,58757} It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.{58758} N-Desbutyl dronedarone inhibits the binding of 3,3',5-triiodo-L-thyronine (T3; Item No. 16028) to the thyroid hormone receptors TRα1 and TRβ1 (IC50s = 59 and 280 µM for the chicken and human receptors, respectively).{58755} It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 µM, respectively, in cell-free assays).{58756} N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50 = 1.07 µM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 µM, respectively).{58757}

• Artikelnummer: CAY34888-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34888-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK