N-desmethyl Azelastine, CAS 47491-38-3

Formulation: A solid

Formal Name: 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1H-azepin-4-yl)-1(2H)-phthalazinone

Purity: ≥98%

Formula Markup: C21H22ClN3O

Formula Weight: 367,9

Shelf life (days): 1460

CAS Number: 47491-38-3

Notes: N-desmethyl Azelastine is an active metabolite of the histamine H1 receptor antagonist azelastine (Item No. 20873).{62780,62781} It is formed from azelastine primarily by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6 and, to a lesser extent, by CYP1A2.{62781} N-desmethyl Azelastine (1 µM) inhibits acetylcholine-induced depolarization and contractions in isolated human tracheal smooth muscle.{62780} It also inhibits transport of daunorubicin (Item No. 14159) and digoxin (Item No. 22266) in LLC-GA5-CoL150 cells overexpressing P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1; IC50s = 11.8 and 41.8 µM, respectively).{62782}

• Artikelnummer: CAY35429-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35429-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: LC-MS