N-desmethyl Galantamine, CAS 41303-74-6

Formulation: A solid

Formal Name: (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol

Purity: ≥90%

Formula Markup: C16H19NO3

Formula Weight: 273,3

Shelf life (days): 1460

CAS Number: 41303-74-6

Notes: N-desmethyl Galantamine is an alkaloid that has been found in C. asiaticum and is an active metabolite of galantamine (Item No. 17559).{62640,62641,62642,62643,62644} It inhibits acetylcholinesterase (AChE; IC50 = 0.23 µM) and currents induced by ACh (Item No. 23829) by 64.8% in Xenopus oocytes expressing human α7 nicotinic acetylcholine receptors (nAChRs) when used at a concentration of 100 µM.{62641} N-desmethyl Galantamine is cytotoxic to MOLT-4 acute lymphoblastic leukemia cells and LMTK alveolar fibroblasts (IC50s = 0.6 and 0.5 µg/ml, respectively).{62643} It decreases disease severity in a mouse model of acute liver injury induced by carbon tetrachloride when administered at doses of 1 and 10 mg/kg.{62644}

• Artikelnummer: CAY35074-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35074-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe