N-Desmethylclozapine-d8, CAS 1189888-77-4

Formulation: A solid

Formal Name: 8-chloro-11-(piperazin-1-yl-2,2,3,3,5,5,6,6-d8)-5H-dibenzo[b,e][1,4]diazepine

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C17H9ClD8N4

Formula Weight: 320,9

Shelf life (days): 1460

CAS Number: 1189888-77-4

Notes: N-Desmethylclozapine-d8 is intended for use as an internal standard for the quantification of N-desmethylclozapine by GC- or LC-MS. N-Desmethylclozapine is an active metabolite of the atypical antipsychotic clozapine (Item Nos. 12059 / 25779).{25512} It was originally described as an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50 = 7.1 nM in rat choroid plexus) and later as an inverse agonist using human recombinant receptors.{47099,47100} N-Desmethylclozapine is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors, and a partial agonist at dopamine D2 and D3, M1 muscarinic acetylcholine, and 5-HT1A receptors.{47100,25512,47101} N-Desmethylclozapine (30 mg/kg) decreases exploratory locomotor activity and increases prepulse inhibiton of the acoustic startle response in mice.{47102}

• Artikelnummer: CAY26027-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26027-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung