N-Methylcytisine, CAS 486-86-2

Formulation: A solid

Formal Name: (1R,5S)-1,2,3,4,5,6-hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one

Purity: ≥95%

Formula Markup: C12H16N2O

Formula Weight: 204,3

Shelf life (days): 1460

CAS Number: 486-86-2

Notes: N-Methylcytisine is an alkaloid that has been found in L. albus and has diverse biological activities.{53991,63205,46624,63206,63207} It is an agonist of nicotinic acetylcholine receptors (nAChRs) and selectively binds to nAChRs over muscarinic acetylcholine receptors (mAChRs; IC50s = 0.05 and 417 µM, respectively).{53991,63205} It elicits whole-cell currents in Xenopus oocytes expressing α4β2, α4β4, and α7 subunit-containing nAChRs (EC50s = 13, 13, and 340 µM, respectively, for the human receptors).{63205} N-Methylcytisine is nematocidal against B. xylophilus.{46624} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 macrophages (IC50 = 33.3 µM) and proliferation of SMMC-7721 cells when used at a concentration of 4 mg/ml.{63206,63207}

• Artikelnummer: CAY34752-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34752-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK