Nalanthalide, CAS 145603-76-5

Formulation: A solid

Formal Name: 3-[[(1R,4aR,5S,6S,8aR)-6-(acetyloxy)decahydro-5,8a-dimethyl-2-methylene-5-(4-methyl-3-penten-1-yl)-1-naphthalenyl]methyl]-2-methoxy-5,6-dimethyl-4H-pyran-4-one

Purity: ≥70%

Formula Markup: C30H44O5

Formula Weight: 484,7

Shelf life (days): 1460

CAS Number: 145603-76-5

Notes: Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found in Nalanthamala and has potassium channel inhibitory and antiviral activities.{53575} It inhibits binding of the potassium channel inhibitor charybdotoxin (Item No. 24115) to Jurkat cell membranes (IC50 = 3 µM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (Kv) channel Kv1.3 (IC50 = 3.9 µM). Nalanthalide depolarizes T cells in vitro with an EC50 value of 500 nM. It also inhibits HIV-1 integrase activity with IC50 values of 10 and 25 µM in coupled and strand transfer assays, respectively.{37200}

• Artikelnummer: CAY29724
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29724-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK