Nat-20(S)-yne, CAS 1397692-46-4

Formulation: A crystalline solid

Formal Name: 26,27-dinorcholest-5-en-24-yne-3β,20-diol

Purity: ≥90%

Formula Markup: C25H38O2

Formula Weight: 370,6

Shelf life (days): 730

CAS Number: 1397692-46-4

Notes: Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.{21774} 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer.{21991} Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect.{21991} Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules.{17990,17992} Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.{21991}

• Artikelnummer: CAY9001369-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001369-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Click Chemistry