NCS-382 (sodium salt), CAS 131733-92-1

Formulation: A crystalline solid

Formal Name: 2-(5,7,8,9-tetrahydro-5-hydroxy-6H-benzocyclohepten-6-ylidene)-acetic acid, monosodium salt

Purity: ≥95%

Formula Markup: C13H13O3 • Na

Formula Weight: 240,2

Shelf life (days): 1460

CAS Number: 131733-92-1

Notes: NCS-382 is a γ-hydroxybutyrate receptor (GHBR) antagonist (IC50s = 134.1 and 201.3 nM in isolated rat striatal and hippocampal membranes, respectively, in radioligand binding assays).{46598} It is selective for GHBR over GABA binding sites in rat brain synaptic membranes at concentrations of 1 and 10 µM. NCS-382 decreases GHB-induced increases in inositol phosphate accumulation and cGMP levels in isolated rat hippocampal slices (IC50s = 8.6 and 30 µM, respectively). It reduces GHB-induced increases in the time mice spent immobile in the forced swim test, indicating anti-sedative activity, when administered at doses of 1.66 and 2.08 mmol/kg.{46599} NCS-382 decreases spike and wave discharges in audiogenic seizure-susceptible Swiss Rb mice, as well as a rat model of petit mal epilepsy, when administered at a dose of 2.3 mmol/kg.{46598}

• Artikelnummer: CAY29315-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29315-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK