Nebivolol (hydrochloride), CAS 152520-56-4

Nebivolol (hydrochloride), CAS 152520-56-4
Artikelnummer
CAY23660-50
Verpackungseinheit
50 mg
Hersteller
Cayman Chemical

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Formulation: A crystalline solid

Formal Name: (αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol, monohydrochloride

Purity: ≥98%

Formula Markup: C22H25F2NO4 • HCl

Formula Weight: 441,9

Shelf life (days): 1460

CAS Number: 152520-56-4

Notes: Nebivolol is an antagonist of the β1-adrenergic receptor (β1-AR; IC50 = 7.41 nM).{38519} It is selective for β1- over β2-ARs (IC50 = 251 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 and the α1- and α2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5, 2,239, 3,162, >10,000, 5,623, and 10,000 nM, respectively). Nebivolol induces vasodilation in isolated mouse renal arteries (EC50 = 11.36 μM) and decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (Item No. 15592; IC50 = 7 μM).{38521,38522} Nebivolol inhibits proliferation of primary human coronary artery smooth muscle cells (HCASMCs) in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 μM for HCASMCs grown in media containing no growth factor, PDGF-BB, basic FGF, and TGF-β1, respectively).{38523} It is also an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro; IC50 = 60.2 µg/ml), and inhibits SARS-CoV-2 pathogenicity in vitro (IC50 = 0.03 µg/ml).{64706} Formulations containing nebivolol have been used in the treatment of hypertension.
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Artikelnummer CAY23660-50
Hersteller Cayman Chemical
Hersteller Artikelnummer 23660-50
Green Labware Nein
Verpackungseinheit 50 mg
Mengeneinheit STK
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