Nefazodone-d6 (hydrochloride), CAS 1330236-06-0

Formulation: A solid

Formal Name: 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl-1,1,2,2,3,3-d6]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, monohydrochloride

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C25H26ClD6N5O2 • HCl

Formula Weight: 512,5

Shelf life (days): 1460

CAS Number: 1330236-06-0

Notes: Nefazodone-d6 (hydrochloride) is intended for use as an internal standard for the quantification of nefazodone (Item No. 10012642) by GC- or LC-MS. Nefazodone is a serotonin (5-HT), norepinephrine, and dopamine reuptake inhibitor (SNDRI; Kis = 137, 570, 2,380 nM, respectively, in rat brain synaptosomes).{63036} It is also an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as α1- and α2-adrenergic receptors (α2-ARs; Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively).{32156} Nefazodone (100 mg/kg) reduces immobility time in the tail suspension test in gerbils.{63037} However, it is toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation when used at a concentration of 30 µM.{63038} Formulations containing nefazodone have previously been used in the treatment of depression.

• Artikelnummer: CAY34264-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34264-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung