Neoaureothin, CAS 59795-94-7

Formulation: A solid

Formal Name: 2-methoxy-3,5-dimethyl-6-[(2R,4Z)-tetrahydro-4-[(2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)-2,4,6-heptatrien-1-ylidene]-2-furanyl]-4H-pyran-4-one

Purity: ≥98%

Formula Markup: C28H31NO6

Formula Weight: 477,6

Shelf life (days): 1460

CAS Number: 59795-94-7

Notes: Neoaureothin is a bacterial metabolite that has been found in Streptomyces.{49162} It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively).{49163} It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.{49164}

• Artikelnummer: CAY28091-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28091-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK