Netupitant, CAS 290297-26-6

Formulation: A solid

Formal Name: N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-benzeneacetamide

Purity: ≥98%

Formula Markup: C30H32F6N4O

Formula Weight: 578,6

Shelf life (days): 1460

CAS Number: 290297-26-6

Notes: Netupitant is an insurmountable antagonist of the neurokinin-1 (NK1) receptor (Ki = 0.95 nM in CHO cells expressing the human recombinant receptor).{37265} It is selective for human NK1 over human NK2 and NK3 and rat NK1 (Kis = >1,500 nM) and over 50 G protein-coupled receptors, monoamine transporters, and ion channels when used in the nanomolar range.{37266} Netupitant decreases the maximal response to substance P-induced contractions in isolated guinea pig ileum with long-lasting effects. It also dose-dependently inhibits the substance P-induced scratching, biting, and licking response in mice when used at doses ranging from 1-10 mg/kg and decreases NK agonist-induced foot tapping in gerbils (ID50s = 1.5 mg/kg, i.p., or 0.5 mg/kg, oral). Formulations containing netupitant have been used in the treatment of chemotherapy-induced nausea and vomiting.

• Artikelnummer: CAY23809-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23809-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK