Netupitant-d6, CAS 2070015-31-3

Formulation: A solid

Formal Name: N-methyl-α,α-dimethyl-d3-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-benzeneacetamide

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C30H26D6F6N4O

Formula Weight: 584,6

Shelf life (days): 1460

CAS Number: 2070015-31-3

Notes: Netupitant-d6 is intended for use as an internal standard for the quantification of netupitant (Item No. 23809) by GC- or LC-MS. Netupitant is an insurmountable antagonist of the neurokinin-1 (NK1) receptor (Ki = 0.95 nM in CHO cells expressing the human recombinant receptor).{37265} It is selective for human NK1 over human NK2 and NK3 and rat NK1 (Kis = >1,500 nM) and over 50 G protein-coupled receptors, monoamine transporters, and ion channels when used in the nanomolar range.{37266} Netupitant decreases the maximal response to substance P-induced contractions in isolated guinea pig ileum with long-lasting effects. It also dose-dependently inhibits the substance P-induced scratching, biting, and licking response in mice when used at doses ranging from 1 to 10 mg/kg and decreases NK agonist-induced foot tapping in gerbils (ID50s = 1.5 mg/kg, i.p., or 0.5 mg/kg, oral).

• Artikelnummer: CAY28901
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28901-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung