Neuromedin B (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: glycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl-L-methioninamide, 2,2,2-trifluoroacetate

Purity: ≥95%

Formula Markup: C52H73N15O12S • XCF3COOH

Formula Weight: 1132,3

Shelf life (days): 1460

Notes: Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor).{31668} It displays similar affinity for frog [Phe13]bombesin receptors (Ki = 11 nM) and lower affinities for human gastrin-releasing peptide receptor and bombesin receptor subtype 3 (Kis = 440 and 4,800 nM, respectively). Intrathecal administration of NMB (0.1-1 nmol) induces dose-dependent itching behavior in mice.{31670} NMB (50 μg, s.c.) reduces serum thyroid stimulating hormone (TSH) by 30% in mice indicating a role in pituitary-thyroid axis function.{38799} In rodents, NMB is also involved in mediating stress and fear responses, thermoregulation, and can stimulate the contraction of the uterus and gastrointestinal smooth muscle.{28635}

• Artikelnummer: CAY24543
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24543-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK