Neuromedin S (rat) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-leucyl-L-prolyl-L-arginyl-L-leucyl-L-leucyl-L-histidyl-L-threonyl-L-α-aspartyl-L-seryl-L-arginyl-L-methionyl-L-alanyl-L-threonyl-L-isoleucyl-L-α-aspartyl-L-phenylalanyl-L-prolyl-L-lysyl-L-lysyl-L-α-aspartyl-L-prolyl-L-threonyl-L-threonyl-L-seryl-L-leucylglycyl-L-arginyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C193H307N57O49S • XCF3COOH

Formula Weight: 4241,9

Shelf life (days): 1460

Notes: Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).{36532} Neuromedin S (1 nmol, i.c.v.) induces phase shifts in the circadian rhythm of locomotor activity in rats without altering the circadian period length.{36532} It also suppresses food and water intake in a dose-dependent manner when administered to rats during the dark period at doses ranging from 0.1 to 5 nmol.{36533} Co-administration of neuromedin S (1 nmol, i.c.v.) inhibits the ability of neuropeptide Y (Item Nos. 15071 / 24716), ghrelin (Item No. 24458), and agouti-related protein (ARP) to stimulate food intake in rats by greater than 50%. Neuromedin S (0.2 nmol, i.c.v.) increases vasopressin levels in rat plasma within five minutes to levels five times greater than a saline control and decreases urinary volume by 25% during the dark period.{36534}

• Artikelnummer: CAY24547
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24547-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK