Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C134H207N41O36S • XCF3COOH

Formula Weight: 3000,4

Shelf life (days): 1460

Notes: Neuropeptide Y (NPY) (13-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.{5565} NPY (13-36) is an agonist of the NPY receptor Y2 with Ki values of 1.28 and 2.62 nM for the rat recombinant receptor in CHO cells and in rat jejunal crypt cell membranes, respectively.{41607} It inhibits forskolin-induced cAMP accumulation with EC50 values of 300, 2.2, >1,000, and 20 at Y1, Y2, Y4, and Y5 receptors, respectively, in vitro .{41608} NPY (13-36) inhibits basal short circuit currents (EC50 = ~2 µM) and electrical field stimulated-secretory responses in isolated rat jejunal mucosa (EC50 = ~200 nM) but does so less potently than NPY (Item Nos. 24716 / 15071).{41609} NPY (13-36) also reduces the frequency of spontaneous excitatory postsynaptic currents (EPSCs) in the CA3 region of hippocampal slices from wild-type but not Y5 receptor knockout mice.{41610}

• Artikelnummer: CAY24714-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24714-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK