Nifedipine-d6, CAS 1188266-14-9

Formulation: A solid

Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-di(methyl-d3) ester

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C17H12D6N2O6

Formula Weight: 352,4

Shelf life (days): 1460

CAS Number: 1188266-14-9

Notes: Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine (Item No. 11106) by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.

• Artikelnummer: CAY25510-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25510-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung