Nilvadipine, CAS 75530-68-6

Formulation: A crystalline solid

Formal Name: 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-(1-methylethyl) ester

Purity: ≥98%

Formula Markup: C19H19N3O6

Formula Weight: 385,4

Shelf life (days): 1460

CAS Number: 75530-68-6

Notes: Nilvadipine is a dihydropyridine L-type calcium channel blocker.{28544} It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in rats.{53345} It decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer's disease when administered at a dose of 0.03% (w/w) in the diet for 17 and 10 months, respectively.{53346} Nilvadipine (3.2 mg/kg, s.c.) reduces infarct volume in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53347}

• Artikelnummer: CAY21243-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21243-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK