Nisoldipine-d6, CAS 1285910-03-3

Formulation: A solid

Formal Name: 3-methyl 5-(2-(methyl-d3)propyl-3,3,3-d3) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C20H18D6N2O6

Formula Weight: 394,5

Shelf life (days): 1460

CAS Number: 1285910-03-3

Notes: Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine (Item No. 20998) by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{33001,59310} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.

• Artikelnummer: CAY31785-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31785-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung