Nogo-66 (1-40) (human, mouse, rat) (trifluoroacetate salt)

Formulation: A solid

Formal Name: N2-acetyl-L-arginyl-L-isoleucyl-L-tyrosyl-L-lysylglycyl-L-valyl-L-isoleucyl-L-glutaminyl-L-alanyl-L-isoleucyl-L-glutaminyl-L-lysyl-L-seryl-L-α-aspartyl-L-α-glutamylglycyl-L-histidyl-L-prolyl-L-phenylalanyl-L-arginyl-L-alanyl-L-tyrosyl-L-leucyl-L-α-glutamyl-L-seryl-L-α-glutamyl-L-valyl-L-alanyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-valyl-L-glutaminyl-L-lysyl-L-tyrosyl-L-seryl-L-asparaginyl-L-serinamide, monotrifluoroacetate salt

Purity: ≥95%

Formula Markup: C206H324N56O65 • CF3COOH

Formula Weight: 4739,1

Shelf life (days): 1460

Notes: Nogo-66 (1-40) is a peptide fragment of Nogo-A that corresponds to the extracellular domain, Nogo-66, which can induce neurite growth cone collapse in oligodendrocytes.{66166,66167} It is also an antagonist of the Nogo-66 receptor (NgR).{66167} It inhibits binding of the NgR agonist AP-Nogo-66 to, and inhibits growth cone collapse induced by the NgR agonist GST-Nogo-66 in, embryonic day 12 (E12) chick dorsal root ganglia (DRG) explants.{66167} Nogo-66 (1-40) partially reverses axonal outgrowth inhibition induced by purified CNS myelin in E12 chick DRG explants (EC50 = 50 nM). It also induces regeneration of corticospinal tract fibers and improves locomotor function in a rat model of midthoracic spinal cord hemisection injury when administered intrathecally at a dose of 75 µg/kg per day.

• Artikelnummer: CAY35310-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35310-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe