NS 5806, CAS 426834-69-7

Formulation: A crystalline solid

Formal Name: N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-urea

Purity: ≥98%

Formula Markup: C16H8Br2F6N6O

Formula Weight: 574,1

Shelf life (days): 1460

CAS Number: 426834-69-7

Notes: NS 5806 is an activator of the calcium-independent transient outward potassium current (Ito).{54789} It increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a manner dependent on potassium channel interaction protein 2 (KChIP2), in CHO-K1 cells expressing human Kv4.3. NS 5806 increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM).{54790} It reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog heart in a model of heart failure.{54791}

• Artikelnummer: CAY33226-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33226-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK