NS 638, CAS 150493-34-8

Formulation: A solid

Formal Name: 1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-1H-benzimidazol-2-amine

Purity: ≥95%

Formula Markup: C15H11ClF3N3

Formula Weight: 325,7

Shelf life (days): 1460

CAS Number: 150493-34-8

Notes: NS 638 is an inhibitor of the N-type voltage-gated calcium channel Cav2.2 and CNS L-type calcium channels.{69119} It inhibits potassium-induced calcium uptake in chick cortical synaptosomes (IC50 = 3.4 µM) and AMPA-induced GABA release from primary chick cortical neurons (IC50 = 4.3 µM), effects that can be blocked by the N-type calcium channel inhibitor ω-conotoxin GVIA (Item No. 24114) but not the L-type calcium channel inhibitor nifedipine (Item No. 11106). It also inhibits potassium-induced calcium level increases in primary chick cerebellar granule cells (IC50 = 3.4 µM), an effect that can be blocked by nifedipine but not ω-conotoxin GVIA. NS 638 (50 mg/kg) reduces infarct volume in a mouse model of focal ischemia induced by middle cerebral artery occlusion (MCAO) but not in a gerbil model of global ischemia induced by bilateral carotid artery occlusion (BCAO).

• Artikelnummer: CAY37193-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37193-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe