NS 9283, CAS 913830-15-6

Formulation: A crystalline solid

Formal Name: 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

Purity: ≥98%

Formula Markup: C14H8N4O

Formula Weight: 248,2

Shelf life (days): 1460

CAS Number: 913830-15-6

Notes: NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM).{53135} In vivo, NS 9283 potentiates ABT-594 (Item No. 22822) analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis.{53136} It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.{53137}

• Artikelnummer: CAY29189-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29189-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK