ODM-201, CAS 1297538-32-9

Formulation: A crystalline solid

Formal Name: N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

Purity: ≥98%

Formula Markup: C19H19ClN6O2

Formula Weight: 398,9

Shelf life (days): 1460

CAS Number: 1297538-32-9

Notes: ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM).{42404} It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

• Artikelnummer: CAY25643-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25643-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK