Olmesartan Medoxomil-d6, CAS 1127298-67-2

Formulation: A solid

Formal Name: 4-(1-hydroxy-1-methylethyl-d6)-2-propyl-1-[[2’-(2H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C29H24D6N6O6

Formula Weight: 564,6

Shelf life (days): 1460

CAS Number: 1127298-67-2

Notes: Olmesartan medoxomil-d6 is intended for use as an internal standard for the quantification of olmesartan medoxomil (Item No. 11614) by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan (Item No. 23412), a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2 receptor.{20965} Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, when administered at a dose of 10 mg/kg per day, as well as in chow-fed control animals when administered at a dose of 11.4 mg/kg per day.{42446} Olmesartan medoxomil also inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats. Formulations containing olmesartan medoxomil have been used in the treatment of hypertension.

• Artikelnummer: CAY25759-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 25759-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung