Orphenadrine (hydrochloride), CAS 341-69-5

Formulation: A crystalline solid

Formal Name: N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-ethanamine, monohydrochloride

Purity: ≥98%

Formula Markup: C18H23NO • HCl

Formula Weight: 305,8

Shelf life (days): 1460

CAS Number: 341-69-5

Notes: Orphenadrine is a muscarinic acetylcholine receptor (mAChR) antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 receptors, respectively).{25806} Orphenadrine (2-5 mg/kg, i.v.) decreases muscle activity induced by the mAChR agonist oxotremorine in rabbits.{47476} It is also an NMDA receptor antagonist with a Ki value of 6 µM in a radioligand binding assay in human postmortem frontal cortex and an IC50 value of 16.2 µM for inhibiting steady state currents in cultured superior colliculus neurons.{47475} Formulations containing orphenadrine have been used in the treatment of acute painful musculoskeletal conditions, including muscle spasms.

• Artikelnummer: CAY26391-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26391-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK