Ospemifene, CAS 128607-22-7

Formulation: A crystalline solid

Formal Name: 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol

Purity: ≥98%

Formula Markup: C24H23ClO2

Formula Weight: 378,9

Shelf life (days): 1460

CAS Number: 128607-22-7

Notes: Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).{41365} It binds to estrogen receptor α (ERα) and ERβ (Kis = 380 and 410 nM, respectively). It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits estrogen response element-mediated transactivation induced by 17β-estradiol (Item No. 10006315) in a reporter assay using MCF-7 cells. Formulations containing ospemifene have been used in the treatment of vulvar and vaginal atrophy-induced dyspareunia.

• Artikelnummer: CAY23755-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23755-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK