Oxybutynin (hydrochloride), CAS 1508-65-2

Formulation: A crystalline solid

Formal Name: 4-(diethylamino)-2-butyn-1-yl ester α-cyclohexyl-α-hydroxy-benzeneacetic acid, monohydrochloride

Purity: ≥98%

Formula Markup: C22H31NO3 • HCl

Formula Weight: 394

Shelf life (days): 1460

CAS Number: 1508-65-2

Notes: Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively).{39586} It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol; Item No. 14486) in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1 nM, respectively).{39587} Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID50s = 0.062 and 0.089 mg/kg, respectively).{39586} It also increases pupil diameter (PD) and locomotor activity (LMA; ED50s = 0.29 and 0.52 mg/kg, respectively) and decreases small intestinal transit (SIT; ID50 = 0.22 mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder.

• Artikelnummer: CAY23825-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23825-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK