Formulation: A crystalline solid
Formal Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-guanidine
Purity: ≥98%
Formula Markup: C12H17N5
Formula Weight: 231,3
Shelf life (days): 1460
CAS Number: 60559-98-0
Notes: P1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-Kir6) with an EC50 value of 45 nM for SUR2B-Kir6 channel activation.{38539} It is highly selective for SUR2 over SUR1 isoforms (IC50s = 9-46 nM and 1.02 mM, respectively, in a radioligand binding assay). P1075 increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo.{38540} It also reduces infarct size in isolated rabbit hearts via activation of mitochondrial ATP-sensitive potassium channels (KATP; EC50s = 60-90 nM).{38541}