PACAP (1-27) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-histidyl-L-seryl-L-α-aspartylglycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucinamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C142H224N40O39S • XCF3COOH

Formula Weight: 3147,6

Shelf life (days): 1460

Notes: Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.{41551} It binds to PACAP receptors in rat brain membrane (IC50 = 9.55 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 1.1, 1.9, and 0.9 nM, respectively).{41552,41553} PACAP (1-27) stimulates cAMP accumulation in H-SY5Y, SK-N-MC, and T47D cells (EC50s = 0.19, 0.22, and 0.17 nM, respectively).{41553} In vivo, in newborn pigs, PACAP (1-27) (1 μM) induces vasodilation of pial arterioles by 36%.{41554}

• Artikelnummer: CAY24769-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24769-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK