PACAP (1-38) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: L-histidyl-L-seryl-L-α-aspartylglycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucylglycyl-L-lysyl-L-arginyl-L-tyrosyl-L-lysyl-L-glutaminyl-L-arginyl-L-valyl-L-lysyl-L-asparaginyl-L-lysinamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C203H331N63O53S • XCF3COOH

Formula Weight: 4534,3

Shelf life (days): 1460

Notes: Pituitary adenylate cyclase-activating peptide (PACAP) (1-38) is a PACAP receptor agonist with IC50 values of 4, 2, and 1 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.{41551} It binds to PACAP receptors in rat brain membrane (IC50 = 4.45 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 3.6, 13, and 4.7 nM, respectively).{41552,41553} It also stimulates cAMP accumulation in H-SY5Y, SK-N-MC, and T47D cells (EC50s = 0.37, 0.26, and 0.73 nM, respectively).{41553} In vivo, in newborn pigs, PACAP (1-38) (1 μM) induces vasodilation of pial arterioles by 43%.{41554}

• Artikelnummer: CAY24770
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24770-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK