Palmitoyl Serinol, CAS 126127-31-9

Formulation: A crystalline solid

Formal Name: N-[2-hydroxy-1-(hydroxymethyl)ethyl]-hexadecanamide

Purity: ≥95%

Formula Markup: C19H39NO3

Formula Weight: 329,5

Shelf life (days): 365

CAS Number: 126127-31-9

Notes: Palmitoyl serinol is a derivative of 2-palmitoyl glycerol (2-PG; Item No. 17882), an endogenous fatty acid ester that potentiates the signaling and in vivo activity induced by the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160).{9610,10671, 9575} It is a metabolite of human commensal bacteria and an agonist of GPR119, increasing cAMP levels in HEK293 cells expressing GPR119 (EC50 = 9 µM).{39726} Palmitoyl serinol (25 µM) reduces IL-4-induced decreases in the levels of long-chain fatty acid-containing ceramides in IL-4-stimulated HaCaT keratinocytes, an effect that can be blocked by the cannabinoid receptor 1 (CB1) antagonist AM-251.{62556} It also binds to PKCζ and induces apoptosis in F-11 neuroblastoma cells, an effect that can be blocked by the PKCζ inhibitor Gö 6983 (Item No. 13311).{8954}

• Artikelnummer: CAY62175-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 62175-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK