Pam3CSK4 (trifluoroacetate salt)

Formulation: A lyophilized powder

Formal Name: S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C81H156N10O13S • XCF3COOH

Formula Weight: 1510,2

Shelf life (days): 1460

Notes: Pam3CSK4 is a synthetic bacterial lipopeptide that binds to and acts as an agonist at toll-like receptor 2 (TLR2).{38691} It induces proliferation of isolated mouse spleen cells and activates lymphocytes at a concentration of 50 µg/ml.{38692} Pam3CSK4 is a potent immune adjuvant in mice, enhancing the response to antigen, as measured by IgM and IgG levels, when used at a dose of 200 µg/animal. It inhibits Th1 and Th2 responses, suppresses eosinophil infiltration, and induces CD4+ T cell apoptosis in a mouse model of allergic conjunctivitis.{38693} Pam3CSK4 (50 µg) decreases lesion size and parasite burden in genetically-resistant and -susceptible mice when administered with L. major to induce leishmaniasis.{38694} It also enhances Th1 responses and stimulates IL-17 production in the early phase of infection.

• Artikelnummer: CAY24126
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24126-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK