PAP-1, CAS 870653-45-5

Formulation: A solid

Formal Name: 4-(4-phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

Purity: ≥98%

Formula Markup: C21H18O5

Formula Weight: 350,4

Shelf life (days): 1460

CAS Number: 870653-45-5

Notes: PAP-1 is an inhibitor of Kv1.3 voltage-gated potassium channels (EC50 = 2 nM at -80 mV in cells overexpressing the human channel).{58913} It is selective for Kv1.3 over a panel of 22 ion channels, including potassium, sodium, calcium, and chloride channels (EC50s = 45-15,000 nM for all). PAP-1 inhibits anti-CD3 antibody-induced proliferation of isolated human CCR7- effector memory T cells. In vivo, PAP-1 (3 mg/kg) inhibits ovalbumin-induced delayed-type hypersensitivity in rats.

• Artikelnummer: CAY30105-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 30105-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe