PAR2 (1-6) amide (human) (trifluoroacetate salt), CAS 2379569-17-0

Formulation: A solid

Formal Name: (S)-6-amino-2-(2-((2S,3S)-2-((S)-2-((S)-2-amino-3-hydroxypropanamido)-4-methylpentanamido)-3-methylpentanamido)acetamido)-N-((S)-1-amino-3-methyl-1-oxobutan-2-yl)hexanamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C28H54N8O7 • XCF3COOH

Formula Weight: 614,8

Shelf life (days): 1460

CAS Number: 2379569-17-0

Notes: PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.{61701} It binds to NCTC 2544 cells expressing human PAR2 (Ki = 9.64 µM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50 = 0.075 µM).{61702} PAR2 (1-6) amide (100 µM) reduces colony formation of A549 lung cancer cells.{61701} It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 µM.{50355} PAR2 (1-6) amide (5 µmol/kg) induces tear secretion in rats when used in combination with amastatin (Item No. 16719).{61703}

• Artikelnummer: CAY35204-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35204-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK