Paraxanthine-d6, CAS 117490-41-2

Formulation: A crystalline solid

Formal Name: 3,7-dihydro-1,7-di(methyl-d3)-1H-purine-2,6-dione

Purity: ≥99% deuterated forms (d1-d6); ≤1% d0

Formula Markup: C7H2D6N4O2

Formula Weight: 186,2

Shelf life (days): 730

CAS Number: 117490-41-2

Notes: Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine (Item No. 21068) by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine (Item No. 14118).{58128} It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively).{38151} In vivo, paraxanthine (30 mg/kg) increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA (N6-cyclopentyladenosine; Item No. 21448) or the adenosine A2 receptor agonist CGS 21680 (Item No. 17126) in rats not habituated to caffeine.{38150} It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.{38152}

• Artikelnummer: CAY9003564-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9003564-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung