Parecoxib (sodium salt), CAS 198470-85-8

Formulation: A solid

Formal Name: N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-propanamide, monosodium salt

Purity: ≥98%

Formula Markup: C19H17N2O4S • Na

Formula Weight: 392,4

Shelf life (days): 1460

CAS Number: 198470-85-8

Notes: Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib (Item No. 10006120).{47736} It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 µM in HEK293 cells.{47737} It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).{47736}

• Artikelnummer: CAY29017-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29017-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK