Pentagastrin, CAS 5534-95-2

Formulation: A solid

Formal Name: N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide

Purity: ≥98%

Formula Markup: C37H49N7O9S

Formula Weight: 767,9

Shelf life (days): 1460

CAS Number: 5534-95-2

Notes: Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist.{47672} It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM).{47673} Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM).{47674} It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively).{40719} Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

• Artikelnummer: CAY28546-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28546-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK