Permethrin, CAS 52645-53-1

Formulation: A crystalline solid

Formal Name: 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, (3-phenoxyphenyl)methyl ester

Purity: ≥95% (mixture of isomers)

Formula Markup: C21H20Cl2O3

Formula Weight: 391,3

Shelf life (days): 1460

CAS Number: 52645-53-1

Notes: Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.{36375} It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.{36376} Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.{36377} Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.

• Artikelnummer: CAY23821
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23821-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK