PF-05089771 (tosylate), CAS 1430806-04-4

Formulation: A crystalline solid

Formal Name: 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide, monomethylbenzenesulfonate

Purity: ≥98%

Formula Markup: C18H12Cl2FN5O3S2 • C7H8O3S

Formula Weight: 672,6

Shelf life (days): 1460

CAS Number: 1430806-04-4

Notes: PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively).{41748} It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50s = ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50s = 10 and 20 μM, respectively). PF-05089771 is also 1,000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation of the domain IV voltage-sensor domain (VSD4) reduces PF-05089771 potency by approximately 100-fold.

• Artikelnummer: CAY24449-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24449-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK