Phenytoin-d10, CAS 65854-97-9

Formulation: A solid

Formal Name: 5,5-di(phenyl-d5)-2,4-imidazolidinedione

Purity: ≥99% deuterated forms (d1-d10)

Formula Markup: C15H2D10N2O2

Formula Weight: 262,3

Shelf life (days): 1460

CAS Number: 65854-97-9

Notes: Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin (Item No. 24037) by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin (Item No. 23889). Phenytoin is formed from fosphenytoin by tissue phosphatases.{39385} It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner.{38721} Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices (EC50s = 42.8 and 33.5 µM, respectively).{61191} It protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 10 mg/kg).{61192} Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus.

• Artikelnummer: CAY33245-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33245-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung