Piclidenoson, CAS 152918-18-8

Formulation: A crystalline solid

Formal Name: 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide

Purity: ≥98%

Formula Markup: C18H19IN6O4

Formula Weight: 510,3

Shelf life (days): 730

CAS Number: 152918-18-8

Notes: Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM).{52557} It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion, an effect that can be reversed by the adenosine receptor antagonist 8-p-sulfophenyl theophylline.{52556} It reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and decreases the number of lung metastases in a model of metastatic murine melanoma.{52557} Piclidenoson (1 and 3 mg/kg) also reduces colonic inflammatory cell infiltration and damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) and in IL-10-/- mice.{52558}

• Artikelnummer: CAY28445-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28445-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK