(+)-Pilocarpine-d3 (hydrochloride)

Formulation: A solid

Formal Name: (3S,4R)-3-ethyldihydro-4-[(1-(methyl-d3)-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride

Purity: ≥99% deuterated from (d1-d3)

Formula Markup: C11H13D3N2O2 • HCl

Formula Weight: 247,7

Shelf life (days): 1460

Notes: (+)-Pilocarpine-d3 is intended for use as an internal standard for the quantification of (+)-pilocarpine (Item No. 14487) by GC- or LC-MS. (+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (apparent Kis = 6, 8.2, and 6.9 μM, respectively).{48747} It induces salivary secretion in rats when administered intraperitoneally at a dose of 1 mg/kg.{48748} Topical administration of (+)-pilocarpine inhibits methylcellulose-induced increases in intraocular pressure in rabbits in a dose-dependent manner.{48749} (+)-Pilocarpine is a chemoconvulsant that has been used in the generation of temporal lobe epilepsy animal models.{52179,26629,23165} Formulations containing (+)-pilocarpine have been used in the treatment of elevated intraocular pressure and dry mouth.

• Artikelnummer: CAY29078
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29078-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung