Pirenzepine (hydrochloride), CAS 29868-97-1

Formulation: A crystalline solid

Formal Name: 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, dihydrochloride

Purity: ≥98%

Formula Markup: C19H21N5O2 • 2HCl

Formula Weight: 424,3

Shelf life (days): 1460

CAS Number: 29868-97-1

Notes: Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM).{49496} It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively).{49497} It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.{36513}

• Artikelnummer: CAY29527-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29527-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK